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KMID : 0614620020390040248
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Korean Journal of Gastroenterology
2002 Volume.39 No. 4 p.248 ~ p.253
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Intragastric Bile Acid Concentration and Intestinal Metaplasia in the Gastric Mucosa
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Kim Do-Ha
Park Neung-Hwa
Joo Kwang-Ro
Lee Seon-Ho
Kim Sung-Ryul
Yoo Cheol-In
Suh Jae-Hee
Park Jae-Hoo
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Abstract
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Background/Aims: Enterogastric reflux of bile has been suspected as a risk factor of foregut cancer. Thus, we measured total intragastric bile acid to determine association between duodenogastric reflux and development of intestinal
metaplasia known as premalignant gastric mucosal change.
Methods: One hundred and three patients with a functional dyspepsia underwent endoscopy. Subsequently, samples of fasting gastric juice were taken from all patients for analysis of total bile acid. With the specimens from 5 sites of the antrum and body, the degree of intestinal metaplasia was evaluated by the update Sydney System and H. pylori infection was evaluated also by Warthin-Starry staining.
Results: There was a significant correlation between the total bile acid level and the degree of intestinal metaplasia (r=0.278, p=0.005). Moreover, multiple linear regression test showed that the concentration of total bile acid was one of the independent risk factors for intestinal metaplasia regardless of age and H. pylori infection.
Conclusions: These results suggest that intragastric bile acid may affect histologic premalignant changes of the gastric mucosa and thus, duodenogastric reflux may play a role in gastric carcinogenesis.
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KEYWORD
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Duodenogastric reflux, Intestinal metaplasia, Gastric cancer, Bile acid
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